Domino ring-opening–ring-closing enyne metathesis vs enyne metathesis of norbornene derivatives with alkynyl side chains. Construction of condensed polycarbocycles
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چکیده
منابع مشابه
Enyne ring-closing metathesis on heteroaromatic cations.
Cationic heteroaromatic enynes have been employed as substrates in enyne ring-closing metathesis, under an atmosphere of ethylene and using the Hoveyda-Grubbs catalyst, for the first time; the reaction affords new 1-vinyl- and 2-vinyl-substituted 3,4-dihydroquinolizinium salts, useful precursors for biologically relevant cations based on the quinolinizium system.
متن کاملEnyne metathesis (enyne bond reorganization).
Enyne metathesis is a bond reorganization of an alkene and an alkyne to produce a 1,3-diene (eqs 1 and 2 in Scheme 1). It has been used in both intramolecular and intermolecular applications. Enyne metathesis bears a mechanistic kinship to alkene metathesis; however, it is less-studied than alkene metathesis. The enyne bond reorganization is atom economical and is driven by the enthalpic stabil...
متن کاملExploiting domino enyne metathesis mechanisms for skeletal diversity generation.
In the context of diversity-oriented synthesis, the exploration and optimization of the domino metathesis of decorated norbornenes allowed complex polycyclic architectures to be generated in a highly efficient and atom-economical process.
متن کاملRuthenium-catalyzed tandem enyne metathesis/hydrovinylation.
In situ modification of Grubbs' first-generation metathesis catalyst allows for a tandem enyne metathesis/hydrovinylation that is complementary to the regioselectivity of known ruthenium-catalyzed hydrovinylations.
متن کاملRing closing enyne metathesis: a powerful tool for the synthesis of heterocycles.
The ring closing metathesis (RCM) is a powerful method in organic synthesis for the preparation of cyclic compounds by formation of new carbon-carbon bonds. In the past years a particular subclass of the RCM, the ring closing enyne metathesis (RCEYM), has attracted attention due to its synthetic potential in the generation of ring structures with 1,3-diene moieties, which can subsequently be fu...
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2018
ISSN: 1860-5397
DOI: 10.3762/bjoc.14.248